Surgical Modulation of Movement Disorders: Insights into Target-Based Deep Brain Stimulation Outcomes

Authors

  • Samy Hassanen Mohamed, Magdy El-Sayed Hassan Rashed , Amr Mohamed Mohamed El-Bakry, Ahmed El-Shabrawy Sweilam

Keywords:

Movement Disorders, Deep Brain Stimulation, Outcomes.

Abstract

Deep brain stimulation (DBS) has transformed the therapeutic landscape for movement disorders such as Parkinson’s disease (PD), essential tremor (ET), and dystonia. Target selection—including the subthalamic nucleus (STN), globus pallidus internus (GPi), and ventral intermediate nucleus of the thalamus (VIM)—critically shapes outcomes based on symptom profile, cognitive status, and comorbidities. STN-DBS is highly effective for motor symptoms and medication reduction in PD but may adversely affect mood and cognition, particularly in older adults. GPi-DBS offers superior control of dyskinesias and a safer neuropsychological profile, while VIM-DBS remains optimal for tremor management, albeit with limited impact on other symptoms.

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References

Benabid AL, Pollak P, Gao D, et al. Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg. 1996;84(2):203–214.

Krack P, Batir A, Van Blercom N, et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med. 2003;349(20):1925–1934.

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Published

2024-07-30

How to Cite

Samy Hassanen Mohamed, Magdy El-Sayed Hassan Rashed , Amr Mohamed Mohamed El-Bakry, Ahmed El-Shabrawy Sweilam. (2024). Surgical Modulation of Movement Disorders: Insights into Target-Based Deep Brain Stimulation Outcomes. Pegem Journal of Education and Instruction, 14(3), 435–440. Retrieved from https://pegegog.net/index.php/pegegog/article/view/3922

Issue

Vol. 14 No. 3 (2024): PEGEGOG

Section

Article

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