Different expression of acetylcholinesterase, caspase 3 and CD38 proteins and Amyloid β peptide in erythrocytes of β thalassemia major patients

Authors

  • Noor Raisan Ali, Leila Sadeghi, Gholamreza Dehghan

Keywords:

Amyloid β; Iron toxicity; Oxidative stress; Ca2 influx; Acetylcholinesterase; Eryptosis

Abstract

Beta thalassemia (β thalassemia) major is a hereditary disease that makes blood transfusion dependency.These patients suffering from some physiological abnormalities like iron overload, oxidative stress and aggregated β-globin proteins that could also trigger early death in transfused red blood cells (RBCs). This study aimed to evaluated the possible changes which could facilitate the eryptosis and death process in RBCs related to β thalassemia major patients

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References

R. Galanello and R. Origa, "Beta thalassemia," Orphanet journal of rare diseases, vol. 5, pp. 1-15, 2010.

S. Ali et al., "Current status of beta thalassemia and its treatment strategies," Molecular Genetics & Genomic Medicine, vol. 9, no. 12, p.

e1788, 2021.

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Published

2024-06-01

How to Cite

Noor Raisan Ali, Leila Sadeghi, Gholamreza Dehghan. (2024). Different expression of acetylcholinesterase, caspase 3 and CD38 proteins and Amyloid β peptide in erythrocytes of β thalassemia major patients . Pegem Journal of Education and Instruction, 14(2), 371–390. Retrieved from https://pegegog.net/index.php/pegegog/article/view/4125

Issue

Vol. 14 No. 2 (2024): PEGEGOG

Section

Article

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