The Role of 5-Fluorouracil in Basal Cell Carcinoma: From Classic Use to Novel Approaches
Keywords:
5-Fluorouracil , Basal Cell CarcinomaAbstract
Background: Basal cell carcinoma (BCC) is the most prevalent cutaneous malignancy worldwide, accounting forapproximately 80% of all non-melanoma skin cancers. Although surgical excision remains the gold standard for most cases, non-invasive treatment modalities are increasingly sought due to their potential for improved cosmetic outcomes,patient convenience, and suitability in anatomically or functionally challenging sites. Among these options, 5-fluorouracil(5-FU), a pyrimidine analog and antimetabolite chemotherapeutic, has played a significant role in the topical managementof BCC, particularly for superficial subtypes.
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Lear JT, Corner C, Dziewulski P, Fife K, Ross GL, Varma S, et al. Challenges and new horizons in the management of advanced basal cell carcinoma: a UK perspective. Br J Cancer. 2014;111(8):1476-1481.
Bichakjian CK, Armstrong A, Baum C, Bordeaux JS, Brown M, Busam KJ, et al. Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol. 2018;78(3):540-559.
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