Neurotoxic Insults and Alzheimer-Like Neurodegeneration: Mechanisms and Pharmacological Neuroprotection

Authors

  • Mohamed Elsayed Kelany, Noha Abbas Telep, Amira Mohammed Abdel Hamid, Huda Mohamed Miftah Gargoum

Keywords:

Neurotoxic Insults, Alzheimer-Like Neurodegeneration, Pharmacological Neuroprotection

Abstract

Background: Alzheimer’s disease is a complex neurodegenerative disorder traditionally defined by amyloid-βaccumulation and tau pathology; however, growing evidence indicates that environmental and endogenous neurotoxicinsults play a significant contributory role in triggering Alzheimer-like neurodegeneration. Exposure to neurotoxic agents, particularly metals and other environmental toxicants

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References

Lane CA, Hardy J, Schott JM. Alzheimer’s disease. Eur J Neurol. 2018;25(1):59–70.

Reitz C, Mayeux R. Alzheimer disease: epidemiology, diagnostic criteria, risk factors and biomarkers. Biochem Pharmacol. 2014;88(4):640–651.

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Published

2024-03-20

How to Cite

Mohamed Elsayed Kelany, Noha Abbas Telep, Amira Mohammed Abdel Hamid, Huda Mohamed Miftah Gargoum. (2024). Neurotoxic Insults and Alzheimer-Like Neurodegeneration: Mechanisms and Pharmacological Neuroprotection. Pegem Journal of Education and Instruction, 14(3), 930–938. Retrieved from https://pegegog.net/index.php/pegegog/article/view/4870

Issue

Vol. 14 No. 3 (2024): PEGEGOG

Section

Article

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