Biomarkers of Sepsis-Associated Acute Kidney Injury: From Conventional Indicators to Emerging Precision Medicine

Authors

  • Khaled Mohammed Youssef , Ahmed Noaman , Yasser Abdelmonem Abdelsalam Hindy , Ahmed Abdulsaboor Mohamed and Usama Ragab

Keywords:

Sepsis-associated acute kidney injury; Biomarkers; Precision medicine

Abstract

Background: Sepsis-associated acute kidney injury (SA-AKI) is one of the most frequent and devastating complicationsof sepsis, contributing substantially to intensive care unit admissions, prolonged hospitalization, chronic kidney disease,and mortality. Early diagnosis remains challenging because conventional indicators, including serum creatinine and urineoutput, often reflect renal dysfunction only after significant kidney injury has already occurred. This diagnostic delaylimits opportunities for timely intervention and highlights the need for more sensitive and specific biomarkers capable of identifying kidney injury at an earlier stage

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References

Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis

. JAMA. 2016;315(8):801-810. doi:10.1001/jama.2016.0287.

Evans L, Rhodes A, Alhazzani W, et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic

Shock 2021. Crit Care Med. 2021;49(11):e1063-e1143. doi:10.1097/CCM.0000000000005337.

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Published

2024-03-15

How to Cite

Khaled Mohammed Youssef , Ahmed Noaman , Yasser Abdelmonem Abdelsalam Hindy , Ahmed Abdulsaboor Mohamed and Usama Ragab. (2024). Biomarkers of Sepsis-Associated Acute Kidney Injury: From Conventional Indicators to Emerging Precision Medicine. Pegem Journal of Education and Instruction, 14(3), 1197–1208. Retrieved from https://pegegog.net/index.php/pegegog/article/view/5249

Issue

Vol. 14 No. 3 (2024): PEGEGOG

Section

Article

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