The Adipose-Tumor Signaling Network in Colorectal Cancer: Metabolic Reprogramming, Immune Escape, and Therapeutic Vulnerabilities

Authors

  • Shady Abdel-Rahman Ibrahim Assaf , Fouad M. Abutale, Amal A. Zidan , Amrallah A. Mohammed , Asmaa A. Mahmoud

Keywords:

Colorectal cancer, Adipose tissue, Leptin, Tumor microenvironment, Metabolic reprogramming

Abstract

Background: Obesity is increasingly recognized as a biologically active modifier of colorectal cancer (CRC), yet body mass alone does not explain howadipose tissue influences tumor behavior. Dysfunctional visceral fat releases adipokines, cytokines, lipids, and stromal signals that may reshape malignantcell metabolism, angiogenesis, immune surveillance, and treatment response

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References

Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229-263.

Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11(2):8597.

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Published

2024-03-15

How to Cite

Shady Abdel-Rahman Ibrahim Assaf , Fouad M. Abutale, Amal A. Zidan , Amrallah A. Mohammed , Asmaa A. Mahmoud. (2024). The Adipose-Tumor Signaling Network in Colorectal Cancer: Metabolic Reprogramming, Immune Escape, and Therapeutic Vulnerabilities. Pegem Journal of Education and Instruction, 14(3), 1317–1327. Retrieved from https://pegegog.net/index.php/pegegog/article/view/5341

Issue

Vol. 14 No. 3 (2024): PEGEGOG

Section

Article

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